Preheat the oven to 350˚F. Stir the self-rising flour, plain, nonfat Greek yogurt, egg, powdered sugar, and vanilla extract, using a stand mixer or hand mixer, until a ball forms.
Turn onto a floured surface, sprinkle with flour, and knead several times. Roll into a large rectangle (about 12x18 inches).
In a small bowl, mix together the brown sugar, all-purpose flour, and ground cinnamon. Sprinkle the mixture evenly over the dough.
Starting at the short end, tightly roll the dough. Pinch the seam to seal. Evenly cut the roll into 12 slices. Transfer the rolls to a greased 11x7-inch pan.
Bake at 350˚F for 28-32 minutes, until golden brown.
Top with powdered sugar glaze or cream cheese frosting, if desired.
Video
Notes
Store in an airtight container at room temperature for 1-2 days, in the fridge for 3-4 days, or in the freezer for 1-2 months.