Preheat the oven to 425˚F. Combine the self-rising flour and plain, nonfat Greek yogurt with a stand mixer or hand mixer until a ball forms.
Turn out onto a floured surface. Sprinkle with flour, knead a couple of times and form into a ball.
Roll the dough out into a large circle on a floured surface. Move the dough over to a greased baking sheet or pizza stone. Reshape dough to fill the pan.
Top with pizza sauce, shredded cheese, pepperoni, and oregano.
Bake at 425˚F for 17-20 minutes until the crust is golden brown and the cheese is melted.